The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling
01 Pubblicazione su rivista
Catanzaro Giuseppina, Besharat Zein Mersini, Miele Evelina, Chiacchiarini Martina, Po Agnese, Carai Andrea, Marras Carlo Efisio, Antonelli Manila, Badiali Manuela, Raso Alessandro, Mascelli Samantha, Schrimpf Daniel, Stichel Damian, Tartaglia Marco, Capper David, von Deimling Andreas, Giangaspero Felice, Mastronuzzi Angela, Locatelli Franco, Ferretti Elisabetta
DOI: 10.1111/nan.12479
ISSN: 0305-1846
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGGs.