Ongoing electroencephalographic activity associated with cortical arousal in trangenic pdapp mice
Background: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing
electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type
(WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive
condition; IMI PharmaCog project, www.pharmacog.eu).
Objective: The objective was to test if these EEG rhythms might be abnormal in old PDAPP mice
modeling Alzheimer’s disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural