Ricerc@Sapienza

In relazione al metodo di bilanciamento delle reazioni redox in soluzione acquosa, nei manuali universitari di Chimica generale attualmente in commercio, solo alcuni seguono le indicazioni chiare e lineari riportate nei manuali di L. Pauling e di R.J. Gillespie et al. (non più in commercio
da diversi anni).

The NRF2/KEAP1 pathway is a crucial and highly conserved defensive system required to maintain or restore the intracellular homeostasis in response to oxidative, electrophilic and other types of stress conditions. The tight control of NRF2 function is maintained by a complex network of biological interactions between positive and negative regulators that ultimately ensure context specific activation, culminating in the NRF2-driven transcription of cytoprotective genes.

Di Magno et al. investigate the therapeutic properties of phenformin in Hedgehog-dependent tumors. At clinically relevant doses, phenformin works independent of respiratory complex I through mGPD-mediated increase of the redox state. This promotes CtBP2/Gli1 complex formation and consequent inhibition of Hedgehog transcriptional output and tumor growth.