Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module
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Di Magno L., Manni S., Di Pastena F., Coni S., Macone A., Cairoli S., Sambucci M., Infante P., Moretti M., Petroni M., Nicoletti C., Capalbo C., De Smaele E., Di Marcotullio L., Giannini G., Battistini L., Goffredo B. M., Iorio E., Agostinelli E., Maroder M., Canettieri G.
ISSN: 2211-1247
Di Magno et al. investigate the therapeutic properties of phenformin in Hedgehog-dependent tumors. At clinically relevant doses, phenformin works independent of respiratory complex I through mGPD-mediated increase of the redox state. This promotes CtBP2/Gli1 complex formation and consequent inhibition of Hedgehog transcriptional output and tumor growth.