Ricerc@Sapienza

We read with interest the paper by Giacobbe et al. estimating a cumulative risk of developing at least one bloodstream infection (BSI) episode (largely due to Gram‐positive pathogens) of almost 50% after 30 days at risk in severe COVID‐19 patients. (2) Similarly, Somers et al. reported an increased risk to develop bacterial superinfections, principally represented by Staphylococcus aureus ventilatory associated pneumonia (VAP), in critically ill patients infected with SARS‐CoV‐2 and treated with Tocilizumab.

L'emoglobina e la mioglobin sono state considerate i modelli paradigmatici della funzione delle proteine, al punto da essere stati definiti "gli atomi di idrogeno della biologia" [Frauenfelder et al. Proc. Natl. Acad. Sci. USA, 2003; 100, 8615-8617]. Data questa posizione privilegiata e l'enorme mole di informazione disponibile su queste proteine, il globulo rosso potrebbe apparire come il modello e "l'atomo di idrogeno" della biologia dei sistemi cellulari.

The metabolic efficiency of different microbial groups in carbon source uses and single species storage efficiency is poorly characterized and not adequately represented in most biogeochemical models. It it is proposed here a simple approach for an estimation of the metabolic quotient of fungal isolates. The method is based on the values of substrate use (respiration) and growth (biomass production) obtainable for single fungal isolates in vitro using the Phenotype MicroArray™ system to test the metabolic performance of fungi on different substrates.

Healthy mitochondria are required in cell metabolism and deregulation of underlying mechanisms is often involved in human diseases and neurological disorders. Post-translational modifications of mitochondrial proteins regulate their function and activity, accordingly, impairment of ubiquitin proteasome system affects mitochondria homeostasis and organelle dynamics. In the present study we have investigated the role of the ubiquitin protease Ubp8 in S. cerevisiae respiration. We show that Ubp8 is necessary for respiration and its expression is upregulated in glycerol respiratory medium.