Ricerc@Sapienza

Background: Saliva of mosquitoes contains anti-platelet, anti-clotting, vasodilatory, anti-complement and antiinflammatory
substances that help the blood feeding process. The salivary polypeptides are at a fast pace of
evolution possibly due to their relative lack of structural constraint and possibly also by positive selection on their
genes leading to evasion of host immune pressure.
Results: In this study, we used deep mRNA sequence to uncover for the first time the sialomes of four Amazonian

Objectives: The diagnosis of primary Sjogren’s syndrome (pSS) continues to be difficult and several patients keep
symptomatic for years with different diagnoses before confirmation of pSS. Since the IL-23-IL-17 axis is involved
in the etiopathogenesis of pSS we evaluated by immunohistochemistry and morphometric methods the presence
of IL-17 as well as IL-23 within minor salivary glands (MSG) obtained from patients with uncertain diagnosis of
pSS.
Materials and Methods: 42 patients, with symptoms attributable to pSS, and 8 patients used as a control, were

Primary Sjögren syndrome (SS) is diagnosed based on the American European Consensus Group (AECG) criteria, but lacks specificity, not only in the involvement of salivary glands, but also in extra-glandular involvement. Whole-body somatostatin receptor scintigraphy with 99m Tc-HYNIC-TOC scintigraphy could overcome these limitations. The aims of this study were to evaluate salivary gland uptake of 99m Tc-HYNIC-TOC in untreated patients with de-novo diagnosis of SS as compared to control subjects and as compared to conventional sialoscintigraphy with 99m TcO 4?.