T-cell leukemia

Notch in T-cell development and disease - UNIT

Notch in T-cell development and disease - UNIT

Notch signaling pathway is deeply involved in T-cell development and differentiation and, consequently, its dysregulation influences the onset and progression of different diseases, including T-cell leukemia and autoimmune diabetes.

Notch/CXCR4 partnership in acute lymphoblastic leukemia progression

Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Recent advances in chemotherapy have made ALL a curable haematological malignancy. In children, there is 25% chance of disease relapse, typically in the central nervous system. While in adults, there is a higher chance of relapse. ALL may affect B-cell or T-cell lineages. Different genetic alterations characterize the two ALL forms. Deregulated Notch, either Notch1 or Notch3, and CXCR4 receptor signaling are involved in ALL disease development and progression.

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