testicular development

Andrological endocrinology

Our institution has a long-standing tradition in andrological research, with the first academic position being established in Rome in 1981. We have contributed to writing pioneering meta-analyses and national and international guidelines on testosterone replacement therapy (TRT) in male hypogonadism, infertility, and sexual dysfunction. In the past decade, we have focused on developing advanced imaging techniques for testicular disorders. We established the first International School of Ultrasound in Andrology for the European Academy of Andrology.

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Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the Amico-Andrologo survey

Background: Risk factors established during adolescence affect health outcomes in adulthood, although little is known about how adolescent health risk behaviours (HRBs) affect testicular development and reproductive health. Objectives: To assess prevalence of HRBs among last year high school students; to describe the most prevalent andrological disorders in this cohort; to explore HRBs associated with andrological disorders and investigate factors possibly associated with impaired testicular development in puberty.

AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?

It is commonly accepted that testicular function is prevalently regulated by the hypothalamic-pituitary-gonadal axis: The pulsatile secretion of GnRH by the hypothalamus induces pituitary expression of the two gonadotropins FSH and LH, which then stimulate Sertoli and Leydig cells, respectively, therefore regulating steroidogenesis and spermatogenesis. However, a growing body of evidence has recently suggested that other hormones act on the reproductive tract since the early phases of fetal development.