transmission electron microscopy

Unità di Microscopia elettronica

L’unità di ricerca di microscopia elettronica della sezione di Anatomia Umana del Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell'Apparato Locomotore (SAIMLAL), nei suoi quasi 50 anni di attività ha dato sempre un forte contributo allo studio di campioni biomedici mediante microscopia elettronica a scansione ed a trasmissione.

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RET/PTC3 translocation in a rare hemorrhagic brain metastasis of papillary thyroid cancer post Chernobyl radiation affects vessels ultrastructure

Abstract
Background
Slow progression and good prognosis are the usual characteristics of papillary thyroid carcinoma (PTC). The presence of brain metastases (0.4–1.2%) is suggestive of a worse prognosis. RET/PTC rearrangements were particularly prevalent in PTCs developed after Chernobyl nuclear accident.

Transmission Electron Microscopy (TEM) - JEOL JEM F200

Lingua Italiano

The TEM is equipped with high-performance additional packages in order to be not just a 'high resolution electron microscope', but a complete and unique characterization platform able to be a fundamental support for excellence researches in all the different fields of interest for Sapienza.

Rapamycin promotes differentiation increasing ?III-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells

Amine oxidases, which contribute to the regulation of polyamine levels, catalyze the oxidative deamination of polyamines to generate H2O2 and aldehyde(s). In this study, and at least to the best of our knowledge, maize polyamine oxidase (ZmPAO) was used for the first time with the aim of identifying a novel strategy for cancer therapy. The cytotoxicity and the mechanisms of cell death induced by the enzymatic oxidation products of polyamine generated by ZmPAO were investigated.