Ricerc@Sapienza

Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes. A bioinformatic analysis indicated a STAT3 binding site in the upstream region of SHMT2 gene. We demonstrated that in LNCaP, PCa cells' SHMT2 expression is upregulated by the JAK2/STAT3 canonical pathway upon IL-6 stimulation.

DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially
and physiologically ripe aubergine berries, were studied for the antioxidative cytoprotective
properties and anti-HSV-1 activity, in line with the evidence that several antioxidants can impair
viral replication by maintaining reducing conditions in host cells. The antioxidative cytoprotective
effects against tBOOH-induced damage were assessed in Caco2 cells, while antiviral activity was