IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies
01 Pubblicazione su rivista
Gianfelici V, Messina M, Paoloni F, Peragine N, Lauretti A, Fedullo Al, Di Giacomo F, Vignetti M, Vitale A, Guarini A, Chiaretti S, Foà R.
ISSN: 1042-8194
The IL7 receptor a chain, encoded by the IL7R gene, heterodimerizes
with the IL-2Rc (common gamma) chain to
form the IL7 receptor, or with the cytokine receptor-like
factor 2 (CRLF2) for the thymic stromal lymphopoietin
(TSLP) receptor, in both B and T cells . Signals from
the IL7 and TSLP receptors activate the JAK/STAT and
PI3K/Akt/mTOR pathways, and are essential for the normal
development and maintenance of the immune system