Intestinal Inflammation Alters the Expression of Hepatic Bile Acid Receptors Causing Liver Impairment
01 Pubblicazione su rivista
Negroni Anna, Fiaschini Noemi, Palone Francesca, Vitali Roberta, Colantoni Eleonora, Laudadio Ilaria, Oliva Salvatore, Aloi Marina, Cucchiara Salvatore, Stronati Laura
ISSN: 0277-2116
The gut-liver axis has been recently investigated in depth in relation to intestinal and hepatic diseases. Key actors are bile acid (BA) receptors, as farnesoid-X-receptor (FXR), pregnane-X-receptor (PXR) and G-protein-coupled-receptor (TGR5), that control a broad range of metabolic processes as well as inflammation and fibrosis.The present study aims to investigate the impact of intestinal inflammation on liver health with a focus on FXR, PXR and TGR5 expression. The strategy to improve liver health by reducing gut inflammation is also considered. Modulation of BA receptors in the inflamed colonic tissues of Inflammatory Bowel Disease (IBD) pediatric patients is analyzed.