2020
BRITISH JOURNAL OF HAEMATOLOGY

Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

01 Pubblicazione su rivista
Uden T., Bertaina A., Abrahamsson J., Ansari M., Balduzzi A., Bourquin J. -P., Gerhardt C., Bierings M., Hasle H., Lankester A., Mischke K., Moore A. S., Nivison-Smith I., Pieczonka A., Peters C., Sedlacek P., Reinhardt D., Stein J., Versluys B., Wachowiak J., Willems L., Zimmermann M., Locatelli F., Sauer M. G.
ISSN: 0007-1048

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

acute myeloid leukemia allogeneic hematopoietic stem cell transplantation children relapse second hematopoietic stem cell transplantation

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