Ricerc@Sapienza

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs.

The Obsessive Compulsive Drinking Scale (OCDS) was developed to reflect obsessionality and compulsivity related to craving and drinking behaviour for revealing in the long-term drop-out, abstinence and relapse. This study evaluates the early OCDS predictive value in drop-out, abstinence and relapse of patients suffering from Alcohol Use Disorders (AUD) for discovering an OCDS total score cut-off capable of disclosing patients most at-risk of relapse during the beginning of the therapeutic intervention in the Day-Hospital period.

OBJECTIVE: The aim of the study
was to evaluate the relationship between bacterial
vaginosis (BV) and relapse of cervical intraepithelial
neoplasia grade 2 or more (CIN2+) after Loop
electrosurgical excision procedure (LEEP).
PATIENTS AND METHODS: One hundred four
patients who underwent LEEP for CIN2+ were followed
up every six months for three years. Fifty-three
were negative for BV and fifty-one were positive.
Each clinical control included Pap test, colposcopy,
Amsel criteria test, HPV-DNA, and HPV-mRNA test.

Background: Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-
Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble
other neoplastic or inflammatory conditions.
Case presentation: Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell
lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and

Background: The aim of the study was to assess the prognostic significance of nephron-sparing surgery (NSS) without tumor size limits as a risk factor for relapse in children with unilateral Wilms Tumor (WT). Methods: A 28-y retrospective single-center review was performed. Prognostic relevance of age, gender, stage, histology, nephrectomy (N), and NSS was analyzed. Results: Sixty-nine cases (42 females and 27 males) with WT, off-therapy from 21 to 325 mo after chemotherapy mainly based on the International Society of Pediatric Oncology trials, were treated at our institution.

We recently introduced an animal model to study incubation of drug craving after prolonged voluntary abstinence, mimicking the human condition of relapse after successful contingency management treatment. Here we studied the role of the nucleus accumbens (NAc) in this model. We trained rats to self-administer a palatable solution (sucrose 1% + maltodextrin 1%, 6 h/day, 6 days) and methamphetamine (6 h/day, 12 days).

Results from preclinical rodent studies during the last 20 years implicated glutamate neurotransmission in different
brain regions in drug self-administration and rodent models of relapse. These results, along with evidence for druginduced
neuroadaptations in glutamatergic neurons and receptors, suggested that addiction might be treatable by
medications that inhibit glutamatergic responses to drugs of abuse, drug-associated cues, and stressors. This idea is

Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist.

Some people are highly motivated to seek aggressive encounters, and among those who have been incarcerated for such behavior, recidivism rates are high. These observations echo two core features of drug addiction: high motivation to seek addictive substances, despite adverse consequences, and high relapse rates. Here we used established rodent models of drug addiction to determine whether they would be sensitive to "addiction-like" features of aggression in CD-1 mice.

In rats trained to self-administer methamphetamine, extinction responding in the presence of drug-associated contextual and discrete cues progressively increases after withdrawal (incubation of methamphetamine craving). The conditioning factors underlying this incubation are unknown. Here, we studied incubation of methamphetamine craving under different experimental conditions to identify factors contributing to this incubation. We also determined whether the rats' response to methamphetamine priming incubates after withdrawal.