Nanocarriers have been regarded as good candidates for drug delivery vehicles since the discovery of the enhanced permeability and retention effect. Promising examples are magnetoliposomes which are the combination of liposomes with encapsulated magnetic nanoparticles. Recently, it has been demonstrated the feasibility of a smart controlled delivery from magnetoliposomes using pulsed electromagnetic fields without a macroscopic temperature increase.
However, when using magnetoliposome problems in their leakage and stability over time may occur. The solution proposed within this project is the combination of magnetoliposomes and hydrogels polymeric matrix in order to form a drug depot at the targeted site and to control the release rate of drugs in a time dependent manner by means of electromagnetic fields.
