endometrial cancer: comparison of ultrasound characteristics with histopathological and biomolecular patterns

Anno
2021
Proponente Giorgia Perniola - Professore Associato
Sottosettore ERC del proponente del progetto
LS7_1
Componenti gruppo di ricerca
Componente Categoria
Gian Luca Cascialli Componenti strutturati del gruppo di ricerca
Componente Qualifica Struttura Categoria
margherita Fischetti dirigente medico dip di Scienze Materno-infantili Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca
Abstract

Worldwide, endometrial cancer is the fourth most common malignancy of the female genital tract. Approximately 70% of patients have a diagnosis of cancer when the neoplasm is confined to the uterus with a good prognosis: 95% of 5 years overall survival. Prognosis depends on the age of patients, histological type, grade differentiation, tumor size, depth of myometrial involvement, cervical stromal invasion and lymph node metastases. Tumor size, myometrial invasion, vascularization, and cervical stromal involvement cannot be determined by clinical examination. Preoperative examination of these parameters in endometrial cancer patients plays an important therapeutic and prognostic role. Currently, there is no consensus on the use of imaging methods in the preoperative assessment. At present, the transvaginal ultrasound (TV-US) represent one of the best achievable low-cost imaging techniques with a sensivity of 68%, and a specificity of 82% respectively for myometrial involvement. d. We will include in the study consecutive women with histologically confirmed endometrial cancer, planned for surgery and all women will undergo TV-US within 7-10 days prior to surgery to assess the local extent of the tumor and vascularization pattern and uterine artery index. . The aim of the study is to evaluate some characteristics at the ultrasound and to compare them to hystological and bimolecular findings.

ERC
LS4_1, LS4_6
Keywords:
DIAGNOSTICA PER IMMAGINI, GINECOLOGIA, ONCOLOGIA

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