Induction chemotherapy in patients with anal canal cancer: a pilot study
| Componente | Categoria |
|---|---|
| Flaminia De Cristofaro | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Carlo De Felice | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Francesco Maria Drudi | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Francesca De Felice | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Componente | Qualifica | Struttura | Categoria |
|---|---|---|---|
| Ilaria Clementi | dirigente medico | Dipartimento di emergenza e accettazione | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Francesca Galati | post-doc | Scienze radiologiche oncologiche e anatomo patologiche | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
Purpose. To investigate the role of induction chemotherapy (IC) followed by definitive chemoradiotherapy (CRT) in anal canal cancer population with bulky disease at diagnosis.
Methods and materials. To assess patient acceptability and treatment feasibility of IC in patients with bulky anal canal malignant lesion.
Results. Theoretical IC advantages may include tumor down-sizing and early micrometastasis eradication, without affect compliance on subsequent standard CRT, due to improvement of oxygenation and higher intramural concentration of cytotoxic drugs.
Conclusion. Study design should be proven feasible with a satisfactory patient acceptance rate and an optimized workflow. This study is the first trial to investigate use of IC in bulky anal canal cancer population.