Ricerc@Sapienza

Breast cancer is the most frequent malignant tumor in women. Despite mastectomies are increasing, breast conservative surgery remains the standard in breast cancer treatment.
There is still no consensus regarding an adequate resection margin. Re-intervention is required in 20-40% in case of positive margins at histological finding. The essential aim of conservative surgery is to maintain oncological safety associated to an acceptable cosmetic result. It is obvious that it brings major problems in terms of local recurrence which is the reason why it is mandatory to find the most accurate system to avoid positive resection margins. Positive margins have a strong impact on local recurrences, disease free survival and overall survival.
The aim of our study is to evaluate the usefulness of intraoperative tomosynthesis in order to obtain a tumor-free margin section in unique non-multicentric lesions. This could reduce the number of R1 patients better than the 2D intraoperative system.
Including criteria are patients with non-palpable lesions ,any age, excluding patients who undergo mastectomies. Every specimen is marked with stitches and metal clips to identify the resection margins. Tomosynthesis is performed in the OR with Kubtec Mozart, using the standard tomosynthesis technique, which generates multiple low-dose projection images over a 30-degree arc and were reconstructed into a series of 1-mm sections to create a set of parallel slices.
For every specimen will be considered the radiologic distance between tumor margin and resection margin and then verified with the hystological finding. The primary endpoint is to highlight the number of R1 patients and re-intervention rate, comparing it to the number of R1 patients identified with the 2D system.