Role of the histone demethylases KDM5 in breast cancer

Anno
2017
Proponente Rodolfo Negri - Professore Ordinario
Sottosettore ERC del proponente del progetto
Componenti gruppo di ricerca
Componente Categoria
Carlo Presutti Componenti il gruppo di ricerca
Teresa Rinaldi Componenti il gruppo di ricerca
Componente Qualifica Struttura Categoria
Cecilia Mannironi Ricercatore Istituto di Biologia e Patologia Molecolari (IBPM), CNR, Roma Altro personale Sapienza o esterni
Enrico Cundari Ricercatore Istituto di Biologia e Patologia Molecolari (IBPM), CNR, Roma Altro personale Sapienza o esterni
Paola Paci Ricercatore Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti" (IASI), CNR, Roma Altro personale Sapienza o esterni
Abstract

Histone demethylases (HDMs) have a prominent role in epigenetic regulation and are emerging as potential
therapeutic cancer targets. In particular, HDMs of class 5 (KDM5) ,also known as JARID, are over-expressed in different types of cancers and have a prominent role in cancer cells ploriferation and DNA damage repair. In particular, KDM5b (JARID 1B) is up-regulated in 90% of human breast cancers. In order to understand its role in breast cancer cells physiology, we propose:
a - to use different chemical inhibitors of KDM5 catalytic activity and to test their effects on transcriptome, cell survival and DNA damage repair.
b - to study the post-transcriptional regulation of JARID 1B expression by miRNAs potentially targeting the protein and significantly modulated in breast cancer cells and their effects on its functional activities

ERC
Keywords:
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