The departmental Proponent group has obtained the following preliminary findings: 1) Resting state electroencephalographic (EEG) rhythms reflect the fluctuation of cortical arousal and vigilance in a typical clinical setting, namely the EEG recording for few minutes with eyes-closed (i.e. passive condition) and -open (i.e. active condition); 2) These EEG markers were altered in Alzheimer¿s disease, AD (European FP7 ICT project entitled ¿DECIDE¿; Grant Agreement: RI-261593; 2010-2013), and can be translated from human to AD mouse models (European FP7 IMI project entitled "PharmaCog"; Grant Agreement: 115009; 2010-2015); 3) A departmental pilot study showed that mice with glioblastoma were characterized by abnormalities of these EEG markers. In this line, the present project will test in a larger sample of mice whether glioblastoma affects cortical neural synchronization and functional connectivity, as revealed by the above EEG markers. We expect that these EEG markers may reflect the effects of the glioblastoma on cerebral function, thus validating the current research model for future investigations on promising therapeutic approaches.
