Nonceliac gluten sensitivity (NCGS) is an emergent condition, the framework of which is yet unclear. The diagnosis suggested by gluten-dependent symptoms after excluding wheat allergy and celiac disease (CD) is today based only on double blind placebo controlled trial. Recently a promising tool consisting in a gluten oral mucosa patch test has been used to diagnose this illness. Besides, exposure through intestinal mucosa of foods containing nickel (Ni) may cause an hypersensitivity reaction too, defined as allergic contact mucositis (ACM). This condition is reproducible and usable as a specific diagnostic tool by the oral mucosa patch test (omPT), a qualitative and subjective diagnostic tool which it requires a clinical expertise. For this reason, laser doppler perfusion imaging tecnique has been used in oral mucosa patch test in both gluten and Ni ACM diagnosis. Our goal will be investigate on possible inflammatory markers and morphological alterations in biopsies obtained from NCGS and Ni sensitive patients to identify possible new diagnostic tools.
