Ricerc@Sapienza

Background: The kidney has a remarkable capacity to withstand insults for an extended period of time. In the past, the monitoring of patients in clinical trials was primarily based on serum creatinine, blood urea nitrogen, glomerular filtration rate (GFR) and the detection of urinary components and other waste products. However, the diagnostic value of all of these parameters is poor and sensitive and specific tests for early diagnosis of acute kidney injury (AKI) are extremely needed, particularly in patients affected by diseases commonly complicating with renal failure, such as type 2 diabetes and primary hyperparathyroidism (PHPT).
Aim: The primary end point of this study is to establish the potential role of AKI biomarkers in detecting subtle renal damage in diabetes and PHPT patients with normal renal function.
Methods: We will include 40 patients with diabetes, 40 patients with PHPT and 50 healthy age and sex-matched subjects. Exclusion criteria will be GFR Expected results: The project will provide new and intriguing data on the presence of kidney disease in patients with diabetes and PHPT and no apparent reduction of renal function, as measured by creatinine and GFR. Data from the study will therefore open a "new" area of research through the early identification of diabetic and PHPT patients at risk of CKD and therefore provide a strong impact on the clinical outcome of these patients.