Magnetic antennas for possible non-invasive electrochemotherapy treatments mediated by electroporation

Proponente Micaela Liberti - Professore Associato
Sottosettore ERC del proponente del progetto
Componenti gruppo di ricerca
Componente Categoria
Stefania Petralito Componenti il gruppo di ricerca
Francesca Apollonio Componenti il gruppo di ricerca
Componente Qualifica Struttura Categoria
Claudia Consales ricercatore ENEA Casaccia, Centro di Ricerca Altro personale Sapienza o esterni
Barbara Benassi ricercatore ENEA Casaccia, Centro di Ricerca Altro personale Sapienza o esterni

Electroporation in vivo and in vitro is limited by the necessity of electrodes that need to be in contact with the subject to be electroporated. In order to generate electric fields of sufficient strength for electroporation to occur, electrodes generally must be in physical contact with the tissue to be electroporated.
The present project aims to provide evidence that magnetic antenna applicators can efficiently induce electric fields able to electroporate, thus demonstrating, broadly speaking, the feasibility of their use in a non invasive electrochemotherapy for deeply seated tumors. The idea seems winning if one thinks that biological tissues are magnetic transparent (i.e. magnetic field is not altered by the human body) but, due to their conductivity, electric current density and electric field can be easily induced thank to the Faraday's law. The project will be exploited through three main steps: the first step will be to design and realize the magnetic applicator for electroporation, second and third step will be to demonstrate its ability to porate liposomes (experimentally) and real cells (computationally).


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