The research interest of our group is focused on the pathogenetic mechanisms involved in development and progression of solid tumors and lymphoproliferative diseases. Moreover, great attention has been paid to the development of new diagnostic tools for detection of genetic alterations addressable with targeted therapy. In the present research project we propose to investigate the following topics: 1) Detection of ALK gene rearrangements in tumor tissue of patients with pulmonary adenocarcinoma by the use of immunohistochemistry. 2) The clinical, histological and molecular alterations of Burkitt lymphoma occurring in Iraqi children, a country with endemic EBV infection during early infancy. 3) Role of MicroRNAs in pre-neoplastic lesions of the breast.
