Aim of this study will be to analyze incidence, predictors and prognosis of de-novo heart failure occurring at 12 months follow-up in the subset of patients with left ventricular ejection fraction >50% after ST-elevation acute myocardial infarction (STEMI) and without history of previous heart failure (HF). The large database of "Acute Myocardial Infarction Cardiac Imaging" (AMICI) trial will be analyzed. This is a multicentre, prospective, longitudinal study conducted in a cohort of acute STEMI patients studied with cardiac magnetic resonance (CMR). Between May 2005 and May 2014, 512 acute STEMI patients from three tertiary referral centres [244 at University Hospitals Leuven, Leuven, Belgium (Centre A), 157 at La Sapienza University Hospital, Rome, Italy (Centre B), and 111 at Fondazione G. Monasterio, Pisa, Italy (Centre C)] were screened for study enrolment
Inclusion Criteria: All patients consecutively admitted to the cardiology departments of our tertiary hospitals, undergoing primary PCI for ST-segment elevation myocardial infarction, in which cardiac MR was performed within 5 days from admission. Only patients with LVEF > 50% after STEMI and without history of previous HF will be included in this study.
Exclusion Criteria:Patients died in hospital and those with no data on vital status and/or on HF status during follow-up, patients with history of HF, Killip III at admission, in-hospital HF, LVEF
Clinical Endpoints:
- Primary endpoint:
Incidence and determinants of de novo HF at 1 year follow-up
- Secondary endpoints:
- Major adverse coronary events at 1 year follow-up in patients with normal LVEF after STEMI
- Incidence and determinants of LV remodeling at 1 year follow up in these subset of patients
