Non-invasive stimuli-responsive nanocarriers activated by nanosecond pulsed electric field

Anno
2018
Proponente Francesca Apollonio - Professore Ordinario
Sottosettore ERC del proponente del progetto
Componenti gruppo di ricerca
Abstract

There is growing interest in integrating nanotechnology with medicine, with the aim to provide diagnosis and treatment of diseases. In this context drug delivery techniques have emerged as methods to administering a pharmaceutical compound in the site of interest. Therapeutic efficacy may be enhanced by triggering drug release in the desired organ in a controlled manner using a non-invasive external stimulus.
Starting from these considerations, the innovative idea of this project is to demonstrate the proof-of-concept of remotely control of liposomes vesicles, by means of nanosecond pulses electric signal.
Such objective will be pursued combining three steps: the design and realization of laboratory exposure systems as well as of the non-invasive applicator; the synthesis of the liposome and the exposure of the suitable liposome solution.

ERC
PE2_6, PE5_7, PE7_4
Keywords:
CAMPI ELETTROMAGNETICI, ANALISI, MODELLAZIONE E SIMULAZIONE DEI SISTEMI BIOLOGICI, INGEGNERIA ELETTRONICA, NANOPARTICELLE, RILASCIO DI FARMACI

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