Platelet activation index in no obstructive coronary artery disease.

Proponente Stefania Basili - Professore Ordinario
Sottosettore ERC del proponente del progetto
Componenti gruppo di ricerca

Ischemic heart diseases (IHD) are not synonymous with obstructive flow-limiting coronary artery disease (CAD), especially in women presenting with symptoms of myocardial ischemia. No obstructive CAD is considered a plausible reason for worse outcomes in women because it cannot benefit from invasive coronary percutaneous interventions and there is a lack of standard medication approach. Platelets may play a crucial role in the pathogenesis of ischemia in no obstructive CAD as they release several vasoconstrictor molecules, which could account for the microvascular coronary dysfunction behind the ischemia in this specific category of IHD patients. However, scarce data on sex differences of platelet biomarkers are available. Our hypothesis is that compared to men, women with no obstructive CAD exhibit a hyperactivation of platelet function that ultimately sustains the ischemic phenomenon in patients with no obstructive CAD. Therefore, our objectives will be: (i) to analyze sex differences in biomarkers of platelet function in patients with IHD and no obstructive coronary artery disease (Objective 1) ; ii) to assess the association between platelet biomarkers and both short- and long-term clinical outcomes according to sex (Objective 2). We will analyze IHD patients, not on chronic antiplatelet therapy, with available baseline blood samples, clinical and angiographic data. Soluble P selectin (sPs), soluble CD40L (sCD40L), thromboxane B2 (TxB2) will be measured. A sex-stratified biomarkers analysis according to clinical presentation (i.e. acute vs chronic) will be performed. No obstructive disease will be defined for coronary stenosis


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