Ricerc@Sapienza

The Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing cardiovascular disease and type II diabetes.
Prevalence of periodontal disease in patients affected by MetS is considered almost double: peri-implantitis and periodontitis share similarities in pathogenic mechanisms and clinical features, however, its relationship with MetS was never investigated.
Peri-implantitis has been defined as a chronic inflammatory lesion, characterized by peri-implant bone loss, bleeding at probing and suppuration. Is considered sensitive to factors inducing tissue inflammation and systemic oxidative stress and up-regulation of inflammatory cytokines were hypothesized as a possible cause of reduced insulin sensitivity, a key aspect in MetS development.
The purpose of this cross-sectional survey is to evaluate possible relationship between MetS and peri-implant diseases.
The specific aims of this project will be to:
¿ Evaluate clinical and radiographic parameters of dental implants
¿ evaluate microbiological samples from peri-implant sulcus (PIS)
¿ evaluate antibiotic resistance among peri-implant bacteria
¿ investigate the molecular content of peri-implant crevicular fluid (PICF)
The authors will develop and implement a cross-sectional study: consecutive patients affected by metabolic syndrome will be screened to evaluate presence of dental implants with at least 5 years of functional loading.
A bidirectional relationship between peri-implant diseases and metabolic syndrome may be speculated, similar to the one already been reported in literature for periodontal disease.
The project will last 18 months: between M1-M12 recruitment will be carried out and patients will be screened, the first milestone will be reached at conclusion of the enrollment phase (120 patients).
Between M12-M18 microbiological and immunological analysis will be performed and results evaluated.