Ricerc@Sapienza

Administration of drugs using small nanocarriers enables effective delivery and targeting of diseased tissues and organs. Therapeutic efficacy may be enhanced by triggering drug release in the desired organ in a controlled manner using a non invasive external stimulus. Aim of the project is to define how to obtain a controlled release from biocompatible carriers as liposomes loading magnetic nanoparticles in their lipid bilayer. The general aim of the project is to provide a proof-of-concept of the remotely control of the magnetoliposomes, by means of low level magnetic fields. Such objective will be pursued combining three common steps: the optimization of the exposure setup; the synthesis of the magnetoliposome and the exposure of the suitable final solution; the modeling of the interaction mechanism between the field and the liposome membrane bilayer containing nanoparticles.