MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1
01 Pubblicazione su rivista
Vescarelli Enrica, Gerini Giulia, Megiorni Francesca, Anastasiadou Eleni, Pontecorvi Paola, Solito Luciana, De Vitis Claudia, Camero Simona, Marchetti Claudia, Mancini Rita, Benedetti Panici Pierluigi, Dominici Carlo, Romano Ferdinando, Angeloni Antonio, Marchese Cinzia, Ceccarelli Simona
ISSN: 1756-9966
Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood. The aim of this study is to identify target genes within the tumor cells that might cause resistance to Olaparib. We focused on Neuropilin 1 (NRP1), a transmembrane receptor expressed in OC and correlated with poor survival, which has been also proposed as a key molecule in OC multidrug resistance.