Open issues on G3 neuroendocrine neoplasms: back to the future
01 Pubblicazione su rivista
Zatelli Maria Chiara, Guadagno Elia, Messina Erika, Lo Calzo Fabio, Faggiano Antongiulio, Colao Annamaria, Albertelli M., Bianchi A., Circelli L., De Cicco F., Dicitore A., Di Dato C., Di Molfetta S., Fanciulli G., Ferraù F., Gallo M., Giannetta E., Grillo F., Grossrubatscher E., Guarnotta V., Isidori A. M., Kara E., Malandrino Corrado, Modica R., Muscogiuri G., Pizza G., Razzore P., Rota F., Rubino M., Ruggeri R. M., Sciammarella C., Vitale G.
DOI: 10.1530/ERC-17-0507
ISSN: 1351-0088
The recent recognition that grade 3 (G3) neuroendocrine neoplasms (NENs) can be divided into two different categories according to the histopathological differentiation, that is G3 neuroendocrine tumors (NETs) and G3 neuroendocrine carcinomas (NECs) has generated a lot of interest concerning not only the diagnosis, but also the differential management of such new group of NENs. However, several issues need to be fully clarified in order to put G3 NETs and G3 NECs in the right place. The aim of this review is to focus on those issues that are still undetermined starting from the current knowledge, evaluating the available evidence and the possible clinical implications.