Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a dream trial ancillary study
01 Pubblicazione su rivista
Venneri Mary Anna, Hasenmajer, Valeria, Fiore, Daniela, Sbardella Emilia, Pofi, Riccardo, Graziadio, Chiara, Gianfrilli Daniele, Pivonello, Claudia, Negri, Mariarosaria, Naro Fabio, Grossman, Ashley B, Lenzi Andrea, Pivonello, Rosario, Isidori Andrea M
ISSN: 0021-972X
Adrenal insufficiency (AI) requires life-long glucocorticoid replacement. Conventional therapies fail to mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling an organ's circadian function and are influenced by glucocorticoids. However, clock gene expression has never been investigated in AI patients.