Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
01 Pubblicazione su rivista
Mazzoccanti G., Manetto S., Bassan M., Foschini A., Orlandin A., Ricci A., Cabri W., Ismail O. H., Catani M., Cavazzini A., Gasparrini F.
DOI: 10.1039/d0ra01296c
ISSN: 2046-2069
The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.