Thymic epithelial tumors phenotype relies on miR-145-5p epigenetic regulation
01 Pubblicazione su rivista
Bellissimo Teresa, Ganci Federica, Gallo Enzo, Sacconi Andrea, Tito Claudia, DE ANGELIS Luciana, Pulito Claudio, Masciarelli Silvia, Diso Daniele, Anile Marco, Petrozza Vincenzo, Giangaspero Felice, Pescarmona Edoardo, Facciolo Francesco, Venuta Federico, Marino Mirella, Blandino Giovanni, Fazi Francesco
ISSN: 1476-4598
Thymoma and thymic carcinoma are the most frequent subtypes of thymic epithelial tumors (TETs). A relevant advance in TET management could derive from a deeper molecular characterization of these neoplasms. We previously identified a set of microRNA (miRNAs) differentially expressed in TETs and normal thymic tissues and among the most significantly deregulated we described the down-regulation of miR-145-5p in TET. Here we describe the mRNAs diversely regulated in TETs and analyze the correlation between these and the miRNAs previously identified, focusing in particular on miR-145-5p. Then, we examine the functional role of miR-145-5p in TETs and its epigenetic transcriptional regulation.