Analysis of CT features and quantitative texture analysis in patients with lung adenocarcinoma: a correlation with EGFR mutations and survival rates

2017

CLINICAL RADIOLOGY

Analysis of CT features and quantitative texture analysis in patients with lung adenocarcinoma: a correlation with EGFR mutations and survival rates

01 Pubblicazione su rivista

Sacconi Beatrice, Anzidei Michele, Leonardi A., Boni Fabrizio, Saba L., Scipione Roberto, Anile Marco, Rengo Marco, Longo F., Bezzi Mario, Venuta Federico, Napoli Alessandro, Laghi Andrea, Catalano Carlo

DOI: 10.1016/j.crad.2017.01.015

ISSN: 0009-9260

AIM:
To investigate the correlation between conventional computed tomography (CT) features, quantitative texture analysis (QTA), epidermal growth factor receptor (EGFR) mutations, and survival rates in patients with lung adenocarcinoma.
MATERIALS AND METHODS:
Sixty-eight patients were evaluated for conventional CT features and QTA in this retrospective study. A multiple logistic regression analysis and receiver operating characteristics (ROC) curve analysis versus death and EGFR status was performed for CT features and QTA in order to assess correlation between CT features, QTA, EGFR mutations, and survival rates. A p-value RESULTS:
An EGFR mutation was identified in 26/68 tumours (38.2%). A negative association was found between EGFR mutation and emphysema (p CONCLUSION:
Both qualitative and quantitative analysis disclosed potential associations between CT features and QTA parameters, EGFR mutations and prognosis; these correlations need to be confirmed in larger studies to be used as imaging biomarkers in the management of patients affected by lung adenocarcinoma.

radiology nuclear medicine and imaging