Saccone Gabriele, Sen Cihat, Di Mascio Daniele, Galindo Alberto, Grünebaum Amos, Yoshimatsu Jun, Stanojevic Milan, Kurjak Asım, Chervenak Frank, José Rodríguez Suárez María, Maria Gambacorti-Passerini Zita, de los Angeles Anaya Baz María, Vanessa Aguilar Galán Esther, Cuñarro López Yolanda, Antonio De León Luis Juan, Cueto Hernández Ignacio, Herraiz Ignacio, Villalain Cecilia, Venturella Roberta, Rizzo Giuseppe, Mappa Ilenia, Gerosolima Giovanni, Hellmeyer Lars, Königbauer Josefine, Ameli Giada, Frusca Tiziana, Volpe Nicola, Battista Luca Schera Giovanni, Fieni Stefania, Esposito Eutalia, Simonazzi Giuliana, Di Donna Gaetana, Youssef MD Aly, Nunzia Della Gatta Anna, Catello Di Donna Mariano, Chiantera Vito, Buono Natalina, Sozzi Giulio, Greco Pantaleo, Morano Danila, Bianchi Beatrice, Giulia Lombana Marino Maria, Laraud Federica, Ramone Arianna, Cagnacci Angelo, Barra Fabio, Gustavino Claudio, Ferrero Simone, Ghezzi Fabio, Cromi Antonella, Simone Laganà Antonio, Laurita Longo Valentina, Stollagli Francesca, Sirico Angelo, Lanzone Antonio, Driul Lorenza, Cecchini Fabiana, Xodo Serena, Rodriguez Brian, Mercado-Olivares Felipe, Elkafrawi Deena, Sisti Giovanni, Esposito Rosanna, Coviello Antonio, Cerbone Marco, Morlando Maddalena, Schiattarella Antonio, Colacurci Nicola, De Franciscis Pasquale, Cataneo Ilaria, Lenzi Marinella, Sandri Fabrizio, Buscemi Riccardo, Gattei Giorgia, della Sala Francesca, Valori Eleonora, Cristina Rovellotti Maria, Done Elisa, Faron Gilles, Gucciardo Leonardo, Esposito Valentina, Vena Flaminia,
Giancotti Antonella,
Brunelli Roberto,
Muzii Ludovico, Nappi Luigi, Sorrentino Felice, Liberati Marco, Buca Danilo, Leombroni Martina, Di Sebastiano Francesca, Franchi Massimo, Cesare Ianniciello Quintino, Garzon Simone, Petriglia Giuliano, Borrello Leonardo, Josè Nieto-Calvache Albaro, Manuel Burgos-Luna Juan, Kadji Caroline, Carlin Andrew, Bevilacqua Elisa, Moucho Marina, Viana Pinto Pedro, Figueiredo Rita, Morales Roselló José, Loscalzo Gabriela, Martinez-Varea Alicia, Diago Vincente, S Jimenez Lopez Jesús, Yeliz Aykanat Alicia, Cosma Stefano, Carosso Andrea, Benedetto Chiara, Bermejo Amanda, Henrique May Feuerschuette Otto, Uyaniklar Ozlem, Rahimli Ocakouglu Sakine, Atak Zeliha, Gündüz Reyhan, Tustas Haberal Esra, Froessler Bernd, Parange Anupam, Palm Peter, Samardjiski Igor, Taccaliti Chiara, Okuyan Erhan, Daskalakis George, Augusto Moreira de Sa Renato, Pittaro Alejandro, Luisa Gonzalez-Duran Maria, Concheiro Guisan Ana, Özlem Genç Şerife, Zlatohlávková Blanka, Luengo Piqueras Anna, Esteban Oliva Dolores, Pelin Cil Aylin, Api Olus, Antsaklis Panos, Ples Liana, Kyvernitakis Ioannis, Maul Holger, Malan Marcel, Lila Albert, Granese Roberta, Ercoli Alfredo, Zoccali Giuseppe, Villasco Andrea, Biglia Nicoletta, Madalina Ciuhodaru, Costa Elena, Daelemans Caroline, Pintiaux Axelle, Cueto Elisa, Hadar Eran, Dollinger Sarah, Brzezinski-Sinai Noa A., Huertas Erasmo, Arango Pedro, Sanchez Amadeo, Alfonso Schvartzman Javier, Cojocaru Liviu, Turan Sifa, Turan Ozhan, Carmela Di Dedda Maria, Garrote Molpeceres Rebeca, Zdjelar Snezana, Premru-Srsen Tanja, Kornhauser-Cerar Lilijana, Druškovič Mirjam, De Robertis Valentina, Stefanovic Vedran, Nupponen Irmeli, Nelskylä Kaisa, Khodjaeva Zulfiya, Gorina Ksenia A., Sukhikh Gennady T., Maria Maruotti Giuseppe, Visentin Silvia, Cosmi Erich, Ferrari Jacopo, Gatti Alessandra, Luvero Daniela, Angioli Roberto, Puri Ludovica, Palumbo Marco, D’Urso Giusella, Colaleo Francesco, Maria Chiara Rapisarda Agnese, Floriana Carbone Ilma, Manzoli Lamberto, Elena Flacco Maria, Nazzaro Giovanni, Locci Mariavittoria, Guida Maurizio, Di Spiezio Sardo Attilio,
Benedetti Panici Pierluigi, Khalil Asma, Berghella Vincenzo, Bifulco Giuseppe, Scambia Giovanni, Z
Objectives: To evaluate maternal and perinatal outcomes of pregnant women affected by SARS-COV-2.
Methods: This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 73 centers from 22 different countries in Europe, United States, South America, Asia and Australia from February 1, 2020 to April 30, 2020. Confirmed SARS-COV-2 infection was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death.
Results: 388 singleton pregnancies tested positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab were included in the study. The primary outcome was observed in 47/388 women (12.1%). 43/388 women (11.1%) were admitted to ICU, 36/388 (9.3%) required mechanical ventilation, and 3/388 women deceased (0.8%). Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of the study. Among the other 266 women, 6 had spontaneous first-trimester abortion, 3 had elective termination of pregnancy, 6 had stillbirth, and 251 delivered a live-born infant. The rate of preterm birth less than 37 weeks of gestation was 26.3% (70/266). Of the 251 live-born infants, 69/251 (27.5%) were admitted to NICU, with 5 neonatal deaths (2.0%). The overall rate of perinatal death was 4.1% (11/266). Only one infant (1/251, 0.4%) born from a mother tested positive during the third trimester, was found positive to SARS-COV-2 at RT-PCR.
Conclusions: SARS-COV-2 in pregnant women is associated with 0.8% rate of maternal mortality, but 11.1% rate of admission to ICU. The risk of vertical transmission seems to be negligible. This article is protected by copyright. All rights reserved.
