Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy
01 Pubblicazione su rivista
Benamar Houari, Tomassini Lamberto, Venditti Alessandro, Marouf Abderrazak, Bennaceur Malika, Serafini Mauro, Nicoletti Marcello
ISSN: 1478-6419
Four pyrrolizidine alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276–0.769.