Ricerc@Sapienza

OBJECTIVE: The aim of the study
was to evaluate the relationship between bacterial
vaginosis (BV) and relapse of cervical intraepithelial
neoplasia grade 2 or more (CIN2+) after Loop
electrosurgical excision procedure (LEEP).
PATIENTS AND METHODS: One hundred four
patients who underwent LEEP for CIN2+ were followed
up every six months for three years. Fifty-three
were negative for BV and fifty-one were positive.
Each clinical control included Pap test, colposcopy,
Amsel criteria test, HPV-DNA, and HPV-mRNA test.
RESULTS: Patients’ age, presence of BV, positivity
to HPV-DNA and HPV-mRNA tests were analyzed.
The average age of patients was 42.5 ± 8.92 years
(median: 42.5; range from 27 to 58 years). The minimum
follow-up was 6 months and maximum 36
months (average: 22.8 ± 4.53; median: 24). The 10%
of the patients with HPV-mRNA test negative had relapsed,
compared to 45% of patients with HPV-mRNA
test positive. Among the 53 patients without BV
the 20% had relapsed compared with 23% of 51 patients
with diagnosis of BV.
CONCLUSIONS: There is no evidence for higher
percentage of relapse in patients with BV, submitted
to excisional procedure for CIN2+ associated
to HPV-m-RNA test positivity. There is only a correlation
among BV and relapse of CIN2+ lesions after
LEEP.