Chronic inflammatory demyelinating polyradiculoneuropathy: can we make a diagnosis in patients not fulfilling electrodiagnostic criteria?

01 Pubblicazione su rivista
Liberatore Giuseppe, Manganelli Fiore, Doneddu Pietro Emiliano, Cocito Dario, Fazio Raffaella, Briani Chiara, Filosto Massimiliano, Benedetti Luana, Mazzeo Anna, Antonini Giovanni, Cosentino Giuseppe, Jann Stefano, Cortese Andrea, Marfia Girolama Alessandra, Clerici Angelo Maurizio, Siciliano Gabriele, Carpo Marinella, Luigetti Marco, Lauria Giuseppe, Rosso Tiziana, Cavaletti Guido, Santoro Lucio, Peci Erdita, Tronci Stefano, Ruiz Marta, Piccinelli Stefano Cotti, Schenone Angelo, Leonardi Luca, Toscano Antonio, Mataluni Giorgia, Spina Emanuele, Gentile Luca, Nobile-Orazio Eduardo
ISSN: 1351-5101

Background and purpose: The aim was to identify the clinical and diagnostic investigations that may help to support a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients not fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society(EFNS/PNS) electrodiagnostic criteria.Methods: The data from patients with a clinical diagnosis of CIDP included in a national database were retrospectively reviewed.Results: In all, 535 patients with a diagnosis of CIDP were included. This diagnosis fulfilled the EFNS/PNS criteria in 468 patients (87.2%) (definite in430, probable in 33, possible in three, while two had chronic immune sensorypolyradiculopathy). Sixty-seven patients had a medical history and clinical signs compatible with CIDP but electrodiagnostic studies did not fulfill theEFNS/PNS criteria for CIDP. These patients had similar clinical features and frequency of abnormal supportive criteria for the diagnosis of CIDP compared to patients fulfilling EFNS/PNS criteria. Two or more abnormal supportive criteria were present in 40 (61.2%) patients rising to 54 (80.6%) if a history ofa relapsing course as a possible supportive criterion was also included.Increased cerebrospinal fluid proteins and response to immune therapy most frequently helped in supporting the diagnosis of CIDP. Response to therapy

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