A Challenging Task—How to Successfully Separate Theca and Granulosa Cells: A Mandatory Step for Investigating Ovary Steroidogenesis
01 Pubblicazione su rivista
Fedeli Valeria, Monti Noemi, Canipari Rita
ISSN: 2532-5876
The reciprocal interaction in between theca (TCs) and granulosa (GCs) cells plays a pivotal role in al-lowing ovary to display a wide range of physiological functions, including steroidogenesis and reproduction capabilities. For instance, changes in the respective proportion among GCs and TCS have been correlated to progression or recovery from Polycystic Ovary Syn-drome (Bevilacqua, et al. 2019). To investigate how these cells cooperate, it is important to understand how they work in isolation. Therefore, segregation of the two cell clusters constitutes a pre-requisite for planning functional studies on the ovary.