Ricerc@Sapienza

Mesenchymal stem cells (MSCs) are currently being tested in preclinical and clinical trials for their ability to foster wound healing and tissue regeneration [1]. They are well known to show a therapeutic potential largely depending on their ability to secrete proregenerative cytokines, making these cells an attractive option for improving the treatment of chronic wounds. The wound microenvironment is a miscellaneous key factor in the local management of the healing process: players such as the extracellular matrix or the resident and recruited cells with paracrine activity are able to determine the way and the appropriateness of the regenerative processes [2]. Dental-derived mesenchymal stem cells (D-dMSCs) are an intriguing milestone of the regenerative medicine, with regard to their potential of differentiating into osteogenic, adipogenic, and chondrogenic lineages [3–5], possessing in this way the potential to significantly influence the bone and periodontal treatment strategies in the future [6–9]. Despite the multiple barriers to their clinical use, MSCs or D-dMSCs have shown sufficient promise to garner a primary place in the field of translational medicine. In fact, MSC and D-dMSC therapies have significant implications for human health: clinical studies are greatly needed to confirm or stimulate the basic and translational researches aimed at reaching cutting-edge results [10–13].