Clemens Zwergel


Titolo Pubblicato in Anno
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model AUTOIMMUNITY 2016
LSD1 inhibitors: a patent review (2010-2015) EXPERT OPINION ON THERAPEUTIC PATENTS 2016
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2016
One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2016
DNA methyltransferases Inhibitors from natural sources CURRENT TOPICS IN MEDICINAL CHEMISTRY 2016
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation FUTURE MEDICINAL CHEMISTRY 2016
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells JOURNAL OF MEDICINAL CHEMISTRY 2015
Emerging approaches for histone deacetylase inhibitor drug discovery EXPERT OPINION ON DRUG DISCOVERY 2015
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas CANCER RESEARCH 2015


  • LS1_13


  • Life-science technologies & biotechnologies

Interessi di ricerca

Dr. Clemens Zwergel is currently an Assistant Professor (RTD-A) at the Sapienza University of Rome. In the last years he proved to be a true European citizen: he moved after his license to practise as Pharmacist from his country of origin (Germany) to Exter (UK) for a Diploma in Pharmaceutical Sciences. Before moving to Italy, he was then a MarieCurie fellow in France (Metz) where he obtained his EuroPhD within the RedCat network. Since 2010, his main research interest lies mainly in the design and synthesis of analogues of natural compounds as well as modulators of epigenetic enzymes with potential applications in cancer, neurodegenerative, metabolic, and infectious diseases resulting in more than 70 publications ( Communication and divulging science are very important aspects for a researcher, thus I would like to increase the visibility of Medicinal Chemistry and the EFMC to the scientific community as well as the general public as well as strengthen the European collaborations together with the other team members.


medicinal chemistry

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