Clemens Zwergel

Pubblicazioni

Titolo Pubblicato in Anno
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni ACS INFECTIOUS DISEASES 2022
Editorial: Multi-target directed ligands for the treatment of cancer FRONTIERS IN ONCOLOGY 2022
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 JOURNAL OF MEDICINAL CHEMISTRY 2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages CHEMMEDCHEM 2022
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? DRUG DISCOVERY TODAY 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Selenium-Containing Agents Acting on Cancer—A New Hope? PHARMACEUTICS 2022
Amphetamine modulation of long-term object recognition memory in rats: influence of stress FRONTIERS IN PHARMACOLOGY 2021
Sirtuins Encyclopedia of Molecular Pharmacology 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction JOURNAL OF MEDICINAL CHEMISTRY 2021
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options DRUG DISCOVERY TODAY 2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders JOURNAL OF MEDICINAL CHEMISTRY 2021
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats NEUROSCIENCE 2021
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation CHEMMEDCHEM 2020
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 EXPERT OPINION ON THERAPEUTIC PATENTS 2020

ERC

  • LS1_13

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Dr. Clemens Zwergel is currently an Assistant Professor (RTD-A) at the Sapienza University of Rome. In the last years he proved to be a true European citizen: he moved after his license to practise as Pharmacist from his country of origin (Germany) to Exter (UK) for a Diploma in Pharmaceutical Sciences. Before moving to Italy, he was then a MarieCurie fellow in France (Metz) where he obtained his EuroPhD within the RedCat network. Since 2010, his main research interest lies mainly in the design and synthesis of analogues of natural compounds as well as modulators of epigenetic enzymes with potential applications in cancer, neurodegenerative, metabolic, and infectious diseases resulting in more than 50 publications (https://www.scopus.com/authid/detail.uri?authorId=37017859900). Communication and divulging science are very important aspects for a researcher, thus I would like to increase the visibility of Medicinal Chemistry and the EFMC to the scientific community as well as the general public as well as strengthen the European collaborations together with the other team members.

Keywords

medicinal chemistry

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