Clemens Zwergel


Titolo Pubblicato in Anno
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design GREEN CHEMISTRY 2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells JOURNAL OF MEDICINAL CHEMISTRY 2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors CURRENT OPINION IN STRUCTURAL BIOLOGY 2023
Editorial: Frontiers in Chemistry: rising stars 2022 FRONTIERS IN CHEMISTRY 2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni ACS INFECTIOUS DISEASES 2022
Editorial: Multi-target directed ligands for the treatment of cancer FRONTIERS IN ONCOLOGY 2022
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 JOURNAL OF MEDICINAL CHEMISTRY 2022
Chemically Diverse S. mansoni HDAC8 Inhibitors Reduced Viability in Worm Larval and Adult Stages CHEMMEDCHEM 2022
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? DRUG DISCOVERY TODAY 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Selenium-Containing Agents Acting on Cancer—A New Hope? PHARMACEUTICS 2022
Amphetamine modulation of long-term object recognition memory in rats: influence of stress FRONTIERS IN PHARMACOLOGY 2021
Sirtuins Encyclopedia of Molecular Pharmacology 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction JOURNAL OF MEDICINAL CHEMISTRY 2021
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options DRUG DISCOVERY TODAY 2021
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders JOURNAL OF MEDICINAL CHEMISTRY 2021


  • LS1_13


  • Life-science technologies & biotechnologies

Interessi di ricerca

Dr. Clemens Zwergel is currently an Assistant Professor (RTD-A) at the Sapienza University of Rome. In the last years he proved to be a true European citizen: he moved after his license to practise as Pharmacist from his country of origin (Germany) to Exter (UK) for a Diploma in Pharmaceutical Sciences. Before moving to Italy, he was then a MarieCurie fellow in France (Metz) where he obtained his EuroPhD within the RedCat network. Since 2010, his main research interest lies mainly in the design and synthesis of analogues of natural compounds as well as modulators of epigenetic enzymes with potential applications in cancer, neurodegenerative, metabolic, and infectious diseases resulting in more than 50 publications ( Communication and divulging science are very important aspects for a researcher, thus I would like to increase the visibility of Medicinal Chemistry and the EFMC to the scientific community as well as the general public as well as strengthen the European collaborations together with the other team members.


medicinal chemistry

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