Ricerc@Sapienza

The scope of the research is to study non canonical pathways involved in cancer proliferation that are under nucleolar control. In cancer cells the nucleolus appears as a prominent nuclear structure involved in ribosome synthesis. Our interest is focused on receptors and transcriptional factors that integrate intra and extracellular stimuli to modulate cell proliferation through the control of nucleolar metabolism. The identification of these molecular players is useful to design new therapeutic strategies to target nucleolar dysfunction linked to iperproliferation.