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isabella.saggio@uniroma1.it
Isabella Saggio
Professore Ordinario
Struttura:
DIPARTIMENTO DI BIOLOGIA E BIOTECNOLOGIE "CHARLES DARWIN"
E-mail:
isabella.saggio@uniroma1.it
Pagina istituzionale corsi di laurea
Curriculum Sapienza
Pubblicazioni
Titolo
Pubblicato in
Anno
Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits
AGING CELL
2018
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate
JCI INSIGHT
2018
Genomic instability and DNA replication defects in progeroid syndromes
NUCLEUS
2018
Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes
SCIENTIFIC REPORTS
2018
The Relationship Between Vitamin B6, Diabetes and Cancer
FRONTIERS IN GENETICS
2018
p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice
FRONTIERS IN GENETICS
2018
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence
OPEN BIOLOGY
2016
Mammalian telomeres and their partnership with lamins
NUCLEUS
2016
No identical "mesenchymal stem cells" at different times and sites: Human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels
STEM CELL REPORTS
2016
Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model
GENE THERAPY
2016
AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance
PLOS GENETICS
2015
The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres
PLOS GENETICS
2015
Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse
JOURNAL OF BONE AND MINERAL RESEARCH
2015
Modeling human neural functionality in vitro: three-dimensional culture for dopaminergic differentiation
TISSUE ENGINEERING. PARTS A, B AND C
2015
Transcriptional response of human neurospheres to helper-dependent CAV-2 vectors involves the modulation of DNA damage response, microtubule and centromere gene groups
PLOS ONE
2015
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Progetti di Ricerca
Comparative analysis of the hematopoietic and stromal (mesenchymal) stem cell compartments in mouse models of physiologic and accelerated aging syndromes
The lamin interacting protein AKTIP in Hutchinson Gilford Progeria Syndrome
The nuclear envelope and telomeric factor AKTIP in replication stress and tumorigenesis
Nuclear and chromatin architecture in cancer diffusion
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