Maria Elena Miranda Banos

Pubblicazioni

Titolo Pubblicato in Anno
Cellular models for the serpinopathies Methods in Molecular Biology 2018
Development of a yeast model to investigate the molecular aspects involved in the neurodegenerative disease FENIB From Stress Response to Tissue Development and Regeneration Pavia, Italy ¿ 28-29 September 2018 2018
Yeast as a tool to unveil the cellular and molecular mechanisms underlying neurodegeneration in FENIB disease 13th International Meeting on Yeast Apoptosis 2018
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB NEUROBIOLOGY OF DISEASE 2017
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization THE FEBS JOURNAL 2017
Polymer toxicity in neurodegeneration FENIB ONCOTARGET 2017
Polymers of Z α1-antitrypsin are secreted in cell models of disease EUROPEAN RESPIRATORY JOURNAL 2016
Embelin binds to human neuroserpin and impairs its polymerisation SCIENTIFIC REPORTS 2016
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior BIOCHEMICAL JOURNAL 2016
Characterising the association of latency with alpha1 antitrypsin polymerisation using a novel monoclonal antibody THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2015
A single-chain variable fragment intrabody prevents intracellular polymerisation of Z alpha1-antitrypsin while allowing its antiproteinase activity THE FASEB JOURNAL 2015
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein BIOCHEMICAL JOURNAL 2015
Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum THE FEBS JOURNAL 2015
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker ELIFE 2015
The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop SCIENTIFIC REPORTS 2015

ERC

  • LS1_4
  • LS3_6
  • LS5_11

Interessi di ricerca

Cell responses to protein aggregation; endoplasmic reticulum stress; neuronal toxicity of neuroserpin polymers that accumulate within the endoplasmic reticulum; mechanism of polymer formation in the serpinopathies; conformation-specific monoclonal antibodies against alpha-1 antitrypsin

Keywords

Neurodegeneration
Endoplasmic reticulum
Alpha 1 antitrypsin
Neuronal death
Familial encephalopathy with neuroserpin inclusion bodies
Neuroserpin

Progetti di Ricerca

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma