Maria Elena Miranda Banos | Ricerc@Sapienza

Pubblicazioni

Le pubblicazioni dell'autore sono raggiungibili sul catalogo IRIS tramite il seguente link

ERC

LS1_4
LS3_6
LS5_11

Interessi di ricerca

Cell responses to protein aggregation; endoplasmic reticulum stress; neuronal toxicity of neuroserpin polymers that accumulate within the endoplasmic reticulum; mechanism of polymer formation in the serpinopathies; conformation-specific monoclonal antibodies against alpha-1 antitrypsin

Keywords

Neurodegeneration

Endoplasmic reticulum

Alpha 1 antitrypsin

Neuronal death

Familial encephalopathy with neuroserpin inclusion bodies

Neuroserpin

Progetti di Ricerca

An inducible neuronal model to uncover new toxicity pathways in the neurodegenerative dementia FENIB
Analysis of cytoskeletal alterations due to mutant neuroserpin in a neuronal model of the neurodegenerative dementia FENIB
Characterisation of oxidative stress and mitochondrial dysfunction due to neuroserpin polymers in the dementia FENIB
Mitochondrial dysfunction and interaction with the endoplasmic reticulum in a neuronal model of the dementia FENIB
Mechanisms of cellular toxicity activated by neuroserpin polymers in a neuronal model of the neurodegenerative dementia FENIB

Laboratori di ricerca

CU026 p2 222A Biologia Cellulare e delle Serpinopatie