Maria Elena Miranda Banos | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB	CELLULAR AND MOLECULAR LIFE SCIENCES	2022
Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD	BRAIN PATHOLOGY	2021
The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic	SCIENTIFIC REPORTS	2021
Neuroserpin Inclusion Bodies in a FENIB Yeast Model	MICROORGANISMS	2021
Neuroserpin: structure, function, physiology and pathology	CELLULAR AND MOLECULAR LIFE SCIENCES	2021
Association between circulating alpha-1 antitrypsin polymers and lung and liver disease	RESPIRATORY RESEARCH	2021
Glycosylation tunes neuroserpin physiological and pathological properties	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
Embelin as lead compound for new neuroserpin polymerization inhibitors	LIFE	2020
The alpha-1 antitrypsin polymer load correlates with hepatocyte senescence, fibrosis stage and liver-related mortality	CHRONIC OBSTRUCTIVE PULMONARY DISEASES	2020
Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin	JCI INSIGHT	2020
The structural basis for Z α1-antitrypsin polymerization in the liver	SCIENCE ADVANCES	2020
The molecular species responsible for α1-antitrypsin deficiency are suppressed by a small molecule chaperone	THE FEBS JOURNAL	2020
Yeast response to the expression of human proteins involved in proteinopathies	7th conference of Physiology of yeast and filamentous fungi	2019
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism	NEUROBIOLOGY OF DISEASE	2018
α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency	CHEST	2018
Cellular models for the serpinopathies	Methods in Molecular Biology	2018
Development of a yeast model to investigate the molecular aspects involved in the neurodegenerative disease FENIB	From Stress Response to Tissue Development and Regeneration Pavia, Italy ¿ 28-29 September 2018	2018
Yeast as a tool to unveil the cellular and molecular mechanisms underlying neurodegeneration in FENIB disease	13th International Meeting on Yeast Apoptosis	2018
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB	NEUROBIOLOGY OF DISEASE	2017

ERC

LS1_4
LS3_6
LS5_11

Interessi di ricerca

Cell responses to protein aggregation; endoplasmic reticulum stress; neuronal toxicity of neuroserpin polymers that accumulate within the endoplasmic reticulum; mechanism of polymer formation in the serpinopathies; conformation-specific monoclonal antibodies against alpha-1 antitrypsin

Keywords

Neurodegeneration

Endoplasmic reticulum

Alpha 1 antitrypsin

Neuronal death

Familial encephalopathy with neuroserpin inclusion bodies

Neuroserpin

Progetti di Ricerca

Laboratori di ricerca

CU026 p2 222A Biologia Cellulare e delle Serpinopatie