Alessandra Soriani

Pubblicazioni

Titolo Pubblicato in Anno
The senescence journey in cancer immunoediting MOLECULAR CANCER 2024
CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma ISCIENCE 2024
NKG2D engagement on human NK cells leads to DNAM‐1 hypo‐responsiveness through different converging mechanisms EUROPEAN JOURNAL OF IMMUNOLOGY 2023
Doxorubicin–Mediated miR–433 Expression on Exosomes Promotes Bystander Senescence in Multiple Myeloma Cells in a DDR–Independent Manner INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Dendritic cell subsets in cancer immunity and tumor antigen sensing CELLULAR & MOLECULAR IMMUNOLOGY 2023
Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity CANCER IMMUNOLOGY, IMMUNOTHERAPY 2023
NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells CELL DEATH & DISEASE 2023
Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle-associated MICA. Dual role in cancer immunosurveillance JOURNAL OF EXTRACELLULAR VESICLES 2022
Self or Non‐Self? It Is also a Matter of RNA Recognition and Editing by ADAR1 BIOLOGY 2022
GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells FRONTIERS IN IMMUNOLOGY 2022
Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition CELL DEATH & DISEASE 2021
Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation EUROPEAN JOURNAL OF IMMUNOLOGY 2021
Technical note: a wearable radiation measurement system for collection of patient-specific time-activity data in radiopharmaceutical therapy: system design and Monte Carlo simulation results MEDICAL PHYSICS 2021
Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer JOURNAL OF CLINICAL MEDICINE 2020
Bone marrow stromal cell-derived IL-8 upregulates PVR expression on multiple myeloma cells via NF-kB transcription factor CANCERS 2020
The Senescence-Associated Secretory Phenotype (SASP) in the challenging future of cancer therapy and age-related diseases BIOLOGY 2020
Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
Senescent cells: Living or dying is a matter of NK cells JOURNAL OF LEUKOCYTE BIOLOGY 2019
The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in multiple myeloma. modulation by bromodomain and Extra-Terminal (BET) protein inhibitors CELL DEATH & DISEASE 2019

ERC

  • LS3_2
  • LS6_1
  • LS6_3

Interessi di ricerca

My research activities have been mainly conducted in the field of natural innate immunity and tumor immunology, with a specific interest in NK cell phenotype, activation and function. In particular, the main interest of my research activity was to study the interplay between NK cells and tumor cells to dissect the molecular pathways that regulate the expression of NK cell activating ligands on tumor cells (i.e. multiple myeloma, renal cell carcinoma), mainly in response to several chemotherapeutic agents. These studies highlighted the critical contribution of the DNA-damage response and senescence pathways in up-regulating their expression on different types of cancer cells. Furthermore, the analysis of the senescent secretome has elucidated some of the mechanisms capable of improving NK cell-tumor immune surveillance.

In the more recent past my interest is being addressed in studying the innate immune surveillance against high-risk human papillomavirus infection through the characterization of novel immunotherapeutic approaches to restore the intrinsic innate immune response, including IFN production (PRIN 2017, Prot. 20178ALPCM). In these studies, I propose to fill the gap between in vitro and in vivo experimentation by employing a bio-printed 3D platform to recapitulate the HPV-infected stratified epithelium.

Keywords

Natural Killer (NK) cells
tumor immune surveillance
innate immune response
HPV infection

Laboratori di ricerca

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma