Roberta Santarelli

Pubblicazioni

Titolo Pubblicato in Anno
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression BRITISH JOURNAL OF CANCER 2020
KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis INTERNATIONAL JOURNAL OF CANCER 2020
BFRF1 protein is involved in EBV-mediated autophagy manipulation MICROBES AND INFECTION 2020
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway FRONTIERS IN ONCOLOGY 2020
Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV CELLS 2020
EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation AUTOPHAGY 2019
Stat3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation VIROLOGY 2019
Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2019
Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization BIOMOLECULES 2019
EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3 JOURNAL OF LEUKOCYTE BIOLOGY 2018
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2017
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy SCIENTIFIC REPORTS 2017
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation CELLULAR SIGNALLING 2017
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells FREE RADICAL BIOLOGY & MEDICINE 2017
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2017
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression AUTOPHAGY 2016
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2016
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future BIOMED RESEARCH INTERNATIONAL 2015
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2015
Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses JOURNAL OF IMMUNOLOGY RESEARCH 2015

ERC

  • LS3_2
  • LS4_12
  • LS6_6

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

EBV and KSHV gammaherpesviruses: biology, immune escape strategies and molecular mechanisms of oncogenesis.
Novel treatments of EBV- and KSHV-associated malignancies.

Keywords

Herpesvirus 8
Herpesvirus 4
Autophagy/UPR
endmt
EMT Epithelial-Mesenchymal Transition
immune escape
primary effusion lymphoma

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