Martino Luigi Di Salvo | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase	PROTEIN SCIENCE	2024
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse	NATURE COMMUNICATIONS	2024
The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target	THE FEBS JOURNAL	2024
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR	NUCLEIC ACIDS RESEARCH	2023
Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli. A pivotal enzyme in the vitamin B6 salvage pathway	THE FEBS JOURNAL	2023
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR	NUCLEIC ACIDS RESEARCH	2023
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo	JOURNAL OF NEUROCHEMISTRY	2022
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K	JOURNAL OF CELLULAR PHYSIOLOGY	2022
Cuticle modifications and over-expression of the chitin-synthase gene in diflubenzuron-resistant phenotype	INSECTS	2022
Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability	PROTEIN SCIENCE	2022
Knowns and unknowns of vitamin B6 metabolism in escherichia coli	ECOSAL PLUS	2021
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2021
A novel, easy assay method for human cysteine sulfinic acid decarboxylase	LIFE	2021
Physiological and biochemical markers of the sex-specific sensitivity to epileptogenic factors, delayed consequences of seizures and their response to vitamins B1 and B6 in a rat model	PHARMACEUTICALS	2021
Characterization of novel pathogenic variants causing pyridox(Am)ine 5′-phosphate oxidase-dependent epilepsy	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Editorial: PLP-dependent enzymes: extraordinary versatile catalysts and ideal biotechnological tools for the production of unnatural amino acids and related compounds	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY	2020
Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation	THE FEBS JOURNAL	2020
The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage	OPEN BIOLOGY	2020
An engineered escherichia coli strain with synthetic metabolism for in‐cell production of translationally active methionine derivatives	CHEMBIOCHEM	2020
Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy	SCIENTIFIC REPORTS	2020

Progetti di Ricerca

Molecular and physiological studies on pyridoxine 5'-phosphate oxidase (PNPO), an enzyme involved in vitamin B6 metabolism and related to severe neurological disorders